1、TECHNICA1.SPECIFICATIONISO/TS4971editionFirst2O23-O6Nanotechno1.ogiesPerformanceeva1.uationofnanosuspensionscontainingc1.aynanop1.atesforquorumquenchingNanotechno1.ogies-Eva1.uationdesperformancesdesnanosuspensionsdenanofeui1.1.etsd,argi1.epourIequorumquenchingISO2023COPYRIGHTPROTECTEDDOCUMENTISO202
2、3IUirhM*hedbdi1.iUedotherwiseupdhi.or啪UIBndttaeDmkfifiHipB1.andonnet8CH-1214Vernier,GenevaPhone：M1.22749O1.11觥ftte:丽丽BQrgPub1.ishedinSwitzer1.andAnnexA(informative)Re1.ationshipbetweenc1.aynanop1.atecharacteristicsandantibacteria1.performanceA.1.Genera1.Natura1.1.yabundantc1.ays,suchasmontmori1.1.on
3、ite,ha1.1.oysiteandirao!ine,genera1.1.yhavea1.ame1.1.arehajQiiboift!i1piha(roIiiiiuind1.ignnicp1.atcsandandnnoiibeofos1.HceAttfnectt)ftHtndt1.hnkfvouhih;efficacyforinhibitingbacteria1.activity.Ingenera1.,theefficacyisattributedtotheirhighspecificsurfacearea,surfacechargesandfinedispersioninaqueoussu
4、spension,whichrendertheattractionA4s帕rHE照她也酣径由胡驮*HS网融出ib般3福箱MM1.商速喻做OOthen招SKQ观部耿ypefort1.f1.kMi圈1.,w起W玳靛d1.威?W即mens粉mayaffectthespacingen1.argementandsurfaceexposure.13Forexamp1.e,thespecificsurfaceareaofmontmori1.1.onite,exfo1.iatedmontmori1.1.onite,micaandexfo1.iatedmicaareabout750mzg,800mz/g,?用魂
5、Ianand艇k阵岛眠他加出Ve1.y册出船nera1.,曲后整限ft三迩祖C1.ayS三*Bft%n保固屈板蛆geebacteria1.ce1.1.wa1.1.andstrengthenitsantibaiddtsuqjensionSBvcafiotItectouriSiipehratnttijtiyodynamicdne5erih(hdDuraqueoussuspensionconcentrationcan1.eadanaggregatedoragg1.omerateform,orthesurfaceionicchargescanbeso1.vatedbythepo1.arorganics
6、andwatermo1.ecu1.es网Theaggregationandso1.vationthe!tfeiWttRfi般fhfo曜刷川1。田祖袖碑鲂)hftwhf1.ftta1.届田刖快bf1.kftdpHobviouspropertyofpHdependency.Thephenomenonismain1.yaresu1.tofthec1.aynanop1.atecontaining1.argenumberofnew1.yexposedhydroxy1.functiona1.itiesonthesurface,whichorigina1.1.yexistedInisciriucingcMo
7、hatiiGwi1.htnitttectantfekijhaTjaAthfCtdMrim1.np1.dtfa1.andtbiH)fffiypeprge110fc1.aynanop1.atebyAnnexB(informative)Corre1.ationbetweenquorumquenchingabi1.ityandantibacteria1.performance1.gwiets11iHajfcas!ht(mshb8cftivrtUxita(tethe(ijQMthnsingafiijpta1.rmbta11rtntth3tscta1.materia1.sprovidetheabi1.it
8、ytoquenchquorumsensingsigna1.mo1.ecu1.es.Thequorumquenchingabi1.ity(QQA)canbequantifiedandexpressedinunitsofmeq/100g.Mo1.ecu1.ar1.ywe1.1.-definedsurfactants三gWWStecationic,interaction.SinePrcsur三SI三taeHeristicth1.MP5theQQismeasuredandprobedbytheinteractionofdaynanop1.ateswithsurfactants.Inotherwords
9、theorigina1.surfactantCMCcandisappearduetothenanop1.ateinteraction.Thenoncova1.entbonding蛆糙窗MeM:哂UOniCSUrfaCtanC初除机能三而削匕端ngintc限眠酎龈郦眠,sur侑阳展渊也interactionwithedgehydroxy1.groupsforanionicsurfactant.曲威Wdifi?IWM&sbac*akur蒯赚Srt蝴腑Mbeco楸SSimU1.瑜姗艇ra巡视册OrcStf1.三1.颗nsingtheeftectivenessofnanop1.ateinteraGU
10、4g-wUUmunicationmo1.ecu1.esofdifferentspecies.Theva1.ueofQQAbyca1.cu1.atingFormu1.a(1)tothecationicsurfactantHDTMA(CT11HaaN(CH3)3Br)and删Hf忠招幽喇&are醐三硼队那部Kate1.ynw明张确认哪砒tin脚/峥叫，ofionicchargesenab1.inganionicexchangereactioninanequiva1.entmannerforthenegative1.ycnargedc1.aynanop1.atewhenquenchingcation
11、icsurfactant.Incontrast,thenotrionicsurfactant,octy1.pheno1.用fe三1.厢5的南9re(VPM舒6*胡卜也疑割胞自值%9QAobhkfef(ard1.f1.etentsCMC.Hence,dependingonthechemica1.natureOfbacteria1.quorumsensingsigna1.s,thenanop)atestendtoexpressadifferentquorumquenchingabi1.itythatsubsequent1.yaffectingthebacteria1.pro1.iferation.
12、1.ft56ttiqhyIMf1.8e忸+ria】CahKth.measurementforthenanop1.ate,squa1.ityandthesubsequentFurther,afternanop1.atequenchingthequorumsensingsigna1.,itcontinuestoadhereontobacteria1.浙曲号椰小殁耻耨防拙淞曲F嫄IkWa1.1.sen艘沁奥旧四弘U1.ar1.曲Rjhty盟涮困*榔dingonewiththepositive1.ychargedcationicsurfactant,isapp1.icab1.eforb1.ocking
13、bacteria1.surfaceforpresumab1.yinhibitingthequorumsensing.Therefore,theovera1.1.antimicrobia1.efficacyiscorre1.ated制中曲M三w哨fe1.W1.entb留Ufi1.浙(喉H蝌Ags1.三ech解fiEBofChemicatmoietiesinc1.udingcarboxy1.,amide,phosphate,hydroxy1.andcarbohydratere1.atedmoieties,17imp1.yingthestrongaffinityfornanop)aw.Basedon
14、theexperimenta1.data,theMBCva1.ueft8三1.W*ft三Xnn4正豳A分附b6VM帕E8aydrOPRM柚必酬IHbHi愧州ereMionicfo1.ddifferenceintheconcentrationrequiredtoinhibitbacteria1.growthbetweennegative1.ychargedc1.aynanop1.ateandmodifiedc1.aynanop1.ate.ThisphenomenonhasconfirmedtheconceptofQQ加藤晡叫跖t.can丽啼ia1.施鼎融跳磁期骗!fe11柘S4V三浏小R曲骼!,
15、觎QQAispragmatica1.1.yusedtodea1.Withthepathogenicbacteriaandabroadspectrumofthebacteria1.co1.oniesinagricu1.turefie1.dsandsoi1.s.AnnexC(informative)Safetyofc1.aynanop1.atesC.1.Natura1.dayBentonitedayhasbeenontheFDAsGRAS1.ist(Genera1.1.yRecognizedasSafe)formanyyears(CFR-Nactebfd(K1.-1.7Ubt(on.i8htt8B
16、ifcqfMMiiiceJhBiniodnjtf(cAfiMj11iRggistryquantitiesofiron,a1.ka1.iesanda1.ka1.ineearthsinthecommercia1.products.C.2C1.ayIianop1.ateThecytotoxicityandgenotoxicityofthec1.aynanop1.atederivedfromtheexfo1.iatedMMTwasstudiedbyDNA此m*geTu2HorhfQUndi1.让UihAherMihIJbtyaSmt中1.ate66ih用I网作烛rin&VaryIgHOTce1.HaE
17、PtbXicity.Themicronuc1.eustestindicatednosignificantchromosoma1.damageonmicefordosesupto500mgkgbodyweightandtheSa1.mone1.1.agenemutationassayonstrainsTA98,TA100,TA102,TA1535,and独药缸把独曼般dim制&由azo1.2出艺部邺林砌岫三fi如概佃tyaM1.1.&SW决购戚&能莫re1.easefromMTTand1.ayereddoub1.ehydroxides,respective1.y,showing1.owcytot
18、oxicityonCHOce1.1.sbe1.ow1000gm1.after121.incubationperiodandadose-dependenteffectafter24hincubation.For国蜩心口用舟丧帆建幅心崂细rtarcj酬狎的驰忸占渺工弗弗Ig叫超dJtiMca1.iterature.Maisanabaeta1.20observedthevarietyofthetoxicityconc1.usionsdescribedinthescientific1.iterature,theauthorfnundthatunmodifieddaynannp1.atesingener
19、a1.inducedCytotOXiCitydependentHft而KedciayCO嵌gM6蹄为弗哈漉你A&.experimenta1.system.MostquaternaryammoniumMostOfrtreTyreVioUSstudiesinrodentstreatedwithunmodifiedMMTshowednoc1.earevidenceof砥取M劭1曲曲州屋VaIUa1.%M鄢P瞅IM郑洲PnanO孤困丽麟喇VUrepor1.M9t1.ong.termdtaryexposuretoMMTat2,0%inSprague-Daw1.eyratsfor28wdidnotshow
20、thepotentia1.toxicity.(2211.iaoeta1.observedthatdaynanop1.ateshowedhighbindingcapacityformycotoxinssuchasforW)三OP1.atediStUrbSh肌叫OUSe勖H三I碘VeI(Wa*%ha6h%bdPorttWr三medtothedietata1.eve1.of0,5%andfedtothepregnantratthroughoutpregnancy,theMMTa1.oneWaSnottoxicandcantight1.ybindaf1.atoxininthegastrointesti
21、na1.tractofanima1.s.(Z4Amodifiedwithin位的幌4N*同点RK希隔吊弘由HJ嘛仃霸uf81.削!由我概&IOfi1.gpsh仲I假碗局呼曲y赳另VCnbeneficia1.toreducethetoxicityofFBIandzear1.enoneinSprague-Daw1.eyrats.C.3Effectofdaynanop1.ateonaqueousorganismsDrinkingwatersafetyhasbeenthreatenedbyincreasingharmfu1.a1.ga1.b1.oomsinwa1.ersources.Atthednda
22、geao闺I甲m,th的inypfatkavystm1.RenHanoi(S(iK)琉叩qtAqRpp11h4i11peidedMicrwc1.tjsaeruginosa,usedintoxicitytestsperformedwithhazardousenvironmenta1.contaminantsre1.easedfromwateror福is阴刑除ion黜趣曲林阳相EBfNSrf1.1.rKItHfi0C幽加注联眠购AmcEifi概itutcmmf煦出慌cntbyISOoftheproductnamed.Equiva1.entproductsmaybeusediftheycanbeSh
23、oWntO1.eadtothesameresu1.ts.10Dm1.tOKtgU1.XMicrocystisae11ginosaKryuchkovaM.,Dani1.ushkinaA.r1.vovY.rPakhrii1.1.inR.*,Eva1.uationoftoxicityofnanoc1.aysand452grapheneoxideinvivo:aParameciumcaudatumstudy*,Environ.Sci.:Nano,2016,3,442-WangM.,OrrA.A.,HeS.,Da1.aijamtsC.,ChiuW.A.,TamamisP.,Phi1.1.ipsT.D.*
24、rSfWnMaR阉1帝邮andParaquatReducingToxinExposuresandWangM.,Phi1.1.1.pT.D.nrPotentia1.App1.icationsofC1.ay-BascdTherapyfortheReductionofPesticideExposuresinHumansandAnima1.s*,App1.Sci.2019r9,5325ISO/TS80004-2:2015,Nanotechno1.ogiesVocabu1.aryPart2:Nano-objects1SOTS80004-4:2011,Nanotechno1.ogiesVocabu1.a
25、ryPart4:Nanostructuredmateria1.s科区mgffq?KnJWW照龙自丽近而g/a皿砒以用册制#g3v麻z/涮碓(W明忖H1.fS柄92Co1.1.oida1.systemsMethodsforzeta-potentia1.determinationPart2:Optica1.惬疔帖W,5三pfj恸阕腑济欣的居阴也WM4/”心Egtheinvitroactivityofantimicrobia1.agentsagainstrapid1.ygrowingaerooicbacteriainvo1.vedininfectiousdiseases4C51fW#0111MethodsforDi1.utionAntimicrobia1.Susceptibi1.ityTestsforBacteriaThQtGrow6tS1.(-,MethodsforDeterminingBactericida1.ActivityofAntimicrobia1.Agents；Approved
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