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7、eOnHCaHkIeHacrof1.iMee11epecMpeHoePyXOBo1.QeTBOOECDTestN2412:2018npe(QHa3naMnoAna11o11homxa-aepwcwMTOKCHyHOCTMHeCzIeAyeMOoxwMWMecoroBemecTBanpwW1.bIXaHKHe3ynbaenoopworoB03BWABTeYeHXeOrpaHWMeHHoro11epof1.aBpeMeHH(28AHeR)h11pe11ocaB11eHH9HaaexHwxRaHHb1.XAnaKOnHMecTBeHHOMOUeHKHPXCKaBabIXaHK知Ochobhompmm
8、mhohepecMpapyoBACea6bnoBKnK)MeHxeBMCnbrraHv1.aHaMOMaTePHaJo,aTaioKeOTPa)KeHHeHOBe山HX11ocvxeHHwBo611acnWCnb1.TaH而B1.QbixaeMbixraeoB.11aponaopoaonew.HOBaaBePCMaPyKOBoaCTBape)*,OcHOBHoeHCCneAoBaHHe11peycMapnBaeHCCne。BaHKeB03aewcBHpexw11n6oneeypo-HMKOHueHTpaukiHMccnef1.yeMoroXMMMqeCKOrOBe1.UeCTBaTeyeHMe
9、28n11e(UeTb1.PeXHeaenbHb1.P1.nepwozi)nouecbYaCoBBAeHbHarpy1111axrpb3yH0,COCTOamKXHeMeweemm11atmCaMUOBw11atwCaMoKaaxeonnbpoaHHoroBOMyXa(rpy11aOTpkIUaTer1.bHO0KOHTPOnf1.)HnHpacBopwenf1.(Hocnenf1.)(rpy1111aKOHTPon夕Hocnenf1.).3aeMxwoHbxyMpB11f1.oBeseHMe24h11oc11eOKoHqaHvmB3AMCiBK.Kanpaewno,*MoHbepraoBoM
10、eRCTBMK)11f1.bAXeAbHeen).hoTa1.OKeaoycwMB03AeHCneBe11eHnecewnAHewbHeAenK).f1.11f1.cex:nBoeneroewcno11b3yjAnarnco11aonorMM,npaoea1111poeAeHMRBA1.F.Ecnw11peAycwopeHbrpybBOCCTaHOBneHHA.wxTaIOKeABpraoanannay6pHxoanbBonRpHoroJ1.aBaXa(BA1.)nyewPWneHMRnerwx.EcnnWCCneAyeMoeXAMWHeCKOeBemeCTboocaecf1.bnernx,p
11、yoBoAHTenbKCCneAOBaHH只foxepaccAHHAocneboqghctbwr(PEO).oopbenoHaoM3wepeHneeroApxaHHRbnernAna11ony11eHMRHHoprau11M0AHHaMMKeOYH1.MeHWanerwxnepMGiuHwwBemeciBa.pmhmnocnAHoco6hhoarya11bH0benynae.ecnnWCCneAyeM0。wmhm-coeBeiuecTBORB11Recf1.TBePAbIMHaoFaepwanoM.f1.nw6o11ee11o11homxapaepwcnwTokcvmhocthmc-c11Gy
12、MoroBQmeCYBaPeKOIqyeTCaBKnK)MarbAOnOr)HMreJ1.bHb1.Gay11banBHbeUCCneAOBaHn.TaKk1KaKTokchkokmHnaUA1.nHOUeHKaCHCTeMHOatokcwhhoctw(HanpviMep,OUeHKaHMMyHHbix,neneHOMHbix,HeBPOn(XHqeeKv1.Xk,hmCePAgHOCOCyAKCrb1.X3o).Boneeopo6hwya3aHHAnoAOn0;IHSTQnbHb1.MHaGnKJAeHHRMHWXaH811H3y11pWBeHbB1.BBeAeHHePyoACTBaOpra
13、HH3aunw3oHMM11ecoroCOTPyAHkHecTBaHpa3nrnA(OECD)DePMOAZeCKH11ePeCMaTPKBaK)TcyMeoMXayMHO0nporpeccannnHSMeneHHAHOPMOUeHKHocMonorv14ecMPeaKUH讯6paxeHWW3aiUkTTb米HBOTHbIXWH3MeH9KU4MXCHOPzaTMBHMXTpe6BaHWW.HCXOAHoePyKOBOf1.CTBOnoHccneaoeaHHK)DoAOCTPOAMHranRUM0HH0Ma只HaHOMaTePHand.OTMeYeH0,mtohb-HOMacTMUbiSToH
14、KOjQHcnepCHbieMaCTMUb1.cymecy)OaHOBPeMeHHobBkUIeHenPePbIBXoCOBOKynXoCTKw11oMyo6pa311bVICKyCCrBeHHb1.XHaHOMaCTHUHMeK)TTeHf1.eHUHioKar11oMepaunwHCCneAyeMonawoc-epe3awcnMcnoc11oco6am11onyMenfi.v13nMecwcbweHMoB11ernxcneayenobo3mokhoctco611OAaTbHOBb丽HOPZaThb:MMADAOn)KeH6wbMeneeHnXPaBeH2mkm.ag-ot1ao3.Ecnw
15、aoHOPMaTMBHewoxe6b11b06ec11eMeH.BOTMeTe06HCCneAOBaHMHao11xho6bb11peCa11eH060CHoBaHe,nMaROnKCaHHewep,11peA11pnHwbxAnaero0CTMxeHMf1.a4apaawon(cm.1).WccneAOBaHMenof1.ocrpoMKHranaUMOHHoAtokcmmhoctmv*c11onb3yoochobhomAnaycaoBnHvRHOPMaTMBHb1.XTpe6aHMMKKOHueHTpauMHBemeCTB11pwOueHKenpC8HOHanbHbiXPkICKOBAJ1.
16、f1.MoPoBbapa6oHnoB.MxYaQKewcnonb3yoAn夕OnPeAeneHHamOUeHKHPHCKoBAnaMe110Bea11pwHCnOnb30BaHv1.HXWPb1.XOMemeHHf1.X.pwTPaHCnOPTKPOBaHMHHf1.11f1.OKPy)KaK)山eHCPeA&3T0PyKOBOACTBO03B0119eTxapaepw3aib11o6o11HbeaebnocneMH0r0paH0r0ex3yeMbBnaXHOMPyKOBOce,11pMBeHbb(1.V1.OCT326432020MEXOCyAPCTBEHHb1.CTAHf1.APTMETO
17、f1.bIMC11b1.TAHMR11OBO3EWCTBmXSMHqECKoH11POf1.VKUHWHAOPAHW3MHE11OBEKATOKCWMHOCTbHOAOCTpanMHranAUHOHHan:2%AHCE)HoCHCSCnOBaHHCMethodsoftestingtheimpactofchemica1.productsonthhumanbody.Subacutcinha1.ationtoxicity28Ha6wb11poaa11n3wpoBaHabcHMeK)IUaaC夕MHopMauwRo6HccnGAyGMOMBeIMeCiBQ.11pwbi6opHUGHTpaMMBQU4
18、CTBaAnaWCCr1。AoBaHKacne-AyeTHCnOnb30BaTbwHopMauw).11Mamy)WeHTvKtnxaugXHMMMeCKycpyypyHh3mko-wmh-hckmgCBOWCiBacc11yMroxkmkmckooBeiuecrea.p3y11babn)6bxMCcneoeaHWMTOKCWMHoCrHinvitroHDHinvivo,11pef1.11onaraeMoe(be)HCnOnb30BaHHe（八）HBePoRTHOCTbBOMeRCTBWaHaMenOBea.HMeK)IUMeCaAaHHb1.eonwHcBHHv3aBnc4Mcncpyyp
19、a-anBH0CTb(O)SARJmAaHHbIGotokcwhhocthcpyypoPOACTBeHHbIXXWMHMecKHXBemeCTb;aaxeAaHHb1.eRPyrMXHCCneAoBaH蔺11oopHoroB03neiCTBHA.11pwHCCHGAOBaHHMTBpOOa3pO3O11AHxAMMOMMTbWHpMaUWK)OO曲叩牧。HKP1.HeTMK8Bnerwx.EcnnBxoeHcCneKBaHX只11pe11o11araoXnHHa6nAao11poB11eHeCHeTeZHotokcunhoctw(HanpHMp.MMMyHoTOKCHUHoCrwHWp0T0K
20、CMMH0CTb.naT0T0KCWHH0CTb.B03WCTBMHCpHH0CO-cyncyx)cMcewy),PyKoBOAHTenbVKXneAoBaHvmMO)KeT11pwHATbpeeneoHeo6xoHMcwBMiOMeHHaOUeHKHcooecByi4norionorkiHcMXKOHeHMbixtomk.HeCMOTpn11ato.moAnanpoeeaeHHAg11nHke11bHb1.XHCCneAOBaHH出M0XTROHMo6ubC3HaMMTe11tH0BPeM凡3T0HeAODXHO6b11bF1.OMexoWAnannaaochobhooHCCnGAOBaHx
21、2.2 EcnwUCCneAyeMOeXHMHYeCKOeBemeCTBO11pezcaB11f1.eco6ohaapo3Dbwo1111oopacBpMMro(bx)MaiepMana(Oe),cneayeinobo3mokhoctkonp。Aenknbpa3MpYaCTHu,Mpon11af1.OnPeReneHHePaCTBOPSMOCth.OnPeAeneHHeapa-epMCTMHaHOMaTGpwanoBphbho(3.(4).2.3 Bf1.bixaewaA(n11wa;IbBeOnaPHa只)paun1111oxoPaCTBOPHMb1.XYaCTH1.1.oopweMeAn
22、eHHobw-BOAATCf1.moxtaKannnBaibCAcKa;Kqb1.Mnoc。GAyIo1.mhmpkoaoiB03AMCTBH.Ce11Hb3a4pxMB11ervxFzoxHoOUeHHTb11yewv3MepeHHAHarpy3nHanerne.MacbanxVaCTHUMO)KeTnepeMeuatcAMinwpoopacnpocpaHATbCf1.bOPraHW3we.VtaMepeHHf1.HarpyawHannFanHcvey311b.CBpaaHHbiec11ervMv(1.A1.N),Moryya3babHaTPaHej1.oKaUgmtoMe6wbAonOnH
23、KTenbHOnoBepf1.eH心PeHHaMKHarpyiKMHaOPraHMW山。Hb.3eb11k6ompaHCnoauwwZOfyT6bbOUeHeHHcy11eoMcwceMHwTokcmmhoctvi.AaHHb1.enoHarpy3eHa11ereHeHCKn2Ma1.oT3H3mhmoctvipe3ynbaoocwo-M3AaHeoHqanbHoenorvNecwxHCCnef1.OBaH口Ha11oao11bHMxmbothom11aOUeHKHPHCKaAraMenOBea.11ozjpo6Hbeya3a-HHA11pWBeHb1.B1.2.4 ArpeccviBHMGn
24、nnpaa1opa*awnGxwmmhckmBemecroawory6bbWCCneAOBaHb1.npnpa3a-11eHHWBKOHUeHTPaUHx,06eC11eMHaK)mWX3a3HHyK)CTeneHbTOKCkNHOCTH11pnB03eWCTBWW3TMXnccne-AyeMbixxnMM4cxbgu4ctbHaXKBOTHbixuenebeKOHUeHrpaUSBAonXHb1.6b11bAOCTaroHHOhh3khmm.mto6wHeb3babrbhom6o11mwAwcpecca.hoaocaoMHbMna11PaCnPoCTPaHeHmkphboh33bwcmmo-
25、CIMKOHMGHTpaunAOTBGTAOypOBHW.KOTOPHeAoCTSraQIPGryrwnOPHoMHayHHOMMGHMWCnbiraHHA.KOHUeHTPaUKXCneweTb6npabBKa)Kf1.OMKOHXPeTHOMCnyMae,11pe110Mv11e11bH0Haochob3a1111aHn-pB3HHoroHaAnG)Ka1.MHM06pa30MMCcneAOBaHWf1.noOnPGAeJ1.eHHIOAna11a0Ha.oopoeno3Bonnnony-MnbwHopuauwoopwHMecowKOHeMHOwoMe,11k)6om11oporepa3f
26、1.paxeHWAmBPeMeHH11pof1.B11eHvA(cm.4.2.14.3.1).HeO6xKnB0THbeCoctorhhmaro11MMnnxMoiHb,OHeBU(QHOWCnbIrbIBaKnMHe6o11bmmmohctpm-pymwe11pn3HanCePbe311oronctohkooncpecca,ao11xhw6wbrywaHHOywepmeneHbi,KhbothwxBCoctorhmharownny11nbBaaxMB0ibx.11om6ujmxBOBPeMaHCnbiTaHna.KPHrePHHAnapnHf1.nf1.p-enf1.o6ywepuiB11eHnnjkwbothwxBcoctorhwharoHnwhdwA)e11oCTPMaKHMHXxwB0THb.
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