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1、Near Infrared Diffuse Optical Tomography (近紅外光擴散光學斷層掃描 ) Abstract Near-infrared (NIR) diffuse optical tomography (DOT) is a biomedical technique for imaging biological tissue that has currently been developed since 1990s. For its sensing mechanism, it has been widely accepted that NIR tomography off
2、ers a way to noninvasively quantify and monitor changes in tissue hemoglobin concentration and oxygen saturation simultaneously, as well as several other chromophores, such as water, lipids, and cytochrome-c-oxidase. The ability to noninvasively quantify these chromophores as a functional image is i
3、mportant for understanding physiological function and pathophysiological changes within tissues, especially for the diagnosis of malignant tumors. In this talk, we will introduce the work done at the Institute of Biomedical Engineering, NCU, to investigate and develop the NIR DOT imaging system in t
4、he past six years. Two generations of NIR DOT scanning and measurement devices, direct current and intensity modulation, using single rotating-source/detector mechanism have been developed. To reconstruct optical-coefficient (absorption and scattering) images, both forward and inverse computation sc
5、hemes have been coded, and further enhanced for rapid computation and edge preservation. Experiments on the influencing factors such as the off-boundary, the contrast of inclusion, and the size ratio of inclusions (tumors) to background for one or two inclusions in a heterogeneousphantom were conduc
6、ted and investigated. Recently, a dual-modality technique based on X-ray mammography is being developed for enhancing the spatial resolution of functional DOT images. Biography Dr. Min-Chun Pan ( 潘敏俊 ) received his Ph.D. degree in mechanical engineering from the Katholieke Universiteit Leuven, Belgi
7、um, in May 1996. In 1996, he was a senior researcher at the Sanyang Industry Corporation, and meanwhile, a junction associate professor at the Department of Forensic Science, Central Police University, Taiwan. After a two-and-half-year career in the industry, in 1999 he jointed the Department of Mec
8、hanical Engineering at the National Central University as an assistant professor. He has been an associate professor and full professor with both the Mechanical Engineering Department and the Institute of Biomedical Engineering since 2003 and 2007, respectively. Dr. Pan s primary interests are in the areas of biomedical signal processing, sensing technology, machine fault diagnostic system, and opto-mechatronic instrument design, etc.