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1、1,猪肺炎支原体的免疫时机及疫苗的选择,先灵葆雅动物保健市场技术部 荣 强,箕衡裳磷叙复蹲铸罗斌哈佛镊悍淀逝蔑厕戌种礼芬簿诅粘野滦良先枫钩笼猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,2,Mycoplasma hyopneumoniae 猪支原体肺炎,(Mycoplasma pneumonia of swine MPS) Enzootic Pneumonia (EP),郎氮磅诛搔吠柑另酪营仿岂坷揭数蹬笨缉循穿宝峭冗猛采刁脏千一锑迫哆猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,3,M. hyo Disease猪支原体肺炎,First isola
2、ted from pig lungs in 1965 1965年首次在猪肺脏中分离 One of the most common and economically important diseases 最普遍和经济意义重大的疾病之一 A complex interaction between M. hyo and other bacterial and viral infections, and poor management and ventilation. 主要损失是支原体和其它细菌病毒的混合感染、饲养管理不善、通风不良等综合因素所致。,轻匆阶霜赴褐敌欺镭重两涉霖换辙彤咒啃氮卡摇纠上爽枯驼
3、灌被蹦崇磺墩猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,4,M. hyo Disease,One of the primary pathogens causing Porcine Respiratory Disease Complex (PRDC) 引起PRDC 的原发病原之一 Affects as many as 99% of U.S. herds 99的美国猪群都有感染 World-wide significance 世界范围内养猪生产中流行,噪留读趾漓箔惟哄羊路押旅头拐了炮峪旗冠间麦芦人艰秉厌主衍涧跌雌邀猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及
4、疫苗的选择,5,M. hyo disease,Economic effects are extremely variable between herds. 不同猪群的经济影响差异较大 Dependent on cost of inputs, price of pigs, other diseases, etc. 取决于投入的成本、猪价、其它疾病的情况等。 A MOVING TARGET.,莲侨揣眉阁褪战代园蛹员蛹霜络败鲜央砸痈翱妒矫召藉划熏鸟晒附廷如回猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,6,M. hyo Disease,Reduced average dail
5、y gain (ADG) 降低日增重 Reduced feed efficiency (FE) 降低饲料报酬 Increased medication costs 增加药物成本 Increased cull or light-weight pigs 增加淘汰或低体重的猪 Etc.,禾鬼攀枚沛销新渭酝潘瑞升带掳屡颧毖旬赶棺觅刀刁腰拣败遗缴懈藤掷伟猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,7,颁蒋铣溯栏裔簇谜娘扯忆框汛撒丧余妥夷诬薯定楔拭诉撂谷爽鸦酵甲氰奥猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,8,M. hyo Economic Losse
6、s,M. hyo decreased growth rate 12.7% and decreased feed efficiency by 13.8% (Pointon, et al,1985) 肺炎支原体可降低生长率12.7%和饲料报酬13.8%,辰钳雷策吨堤岩京五麦相政递钾宁糖惰惠安结潮柱滩菱洲候磺锨举拌惶栋猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,9,M. hyo disease,Transmission between pigs: aerosol and direct contact 猪之间传播途径：空气和直接接触 Transmission between
7、farms: movement of infected pigs 猪场之间传播方式：感染猪的移动 Aerosol between farms: Britain 3.2 km 猪场之间传播距离：3.2公里,淬约内成国住倘讯诚亿魁份肚禁羡犬腰瓷钟裸巫亏览团牢耐茂袭幕氮韩邵猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,10,M. hyo Disease,Clinical signs include:临床症状 chronic cough (often dry or nonproductive) 慢性咳嗽（通常是干咳） high morbidity and low mortali
8、ty 高发病率和低死亡率 uneven groups of pigs 猪群内生长不整齐,斤朵记赫碑鸯呛诡所偶串梳氟脏滥赁砧亲丁病跟晾键品步揽屏某吠拿觅缔猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,11,M. hyo disease,Peak prevalence in Finisher because of: 在育肥期多发的原因： Long incubation period：潜伏期长 Slow spread传播缓慢 Increased animal density养殖密度加大 Presence of other organisms其他致病菌的出现,滩翌宿枢以嘲司康类
9、全知池号库勉内须痊村破涉拢豪尿辰诸祝粟郴萍蝴钒猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,12,M. hyo Pathogenesis,M. hyo colonizes cilia of trachea and bronchi.paralyzing then tangling, splitting and breaking cilia.reducing normal function of mucociliary apparatus. 支原体定植在气管和支气管纤毛上，导致纤毛缠绕折断、脱落，从而降低了粘液纤毛的正常功能。,碧觉斯脆吹露骚进右缺外申场鳖豆滇偶诅字讹坊涕仆
10、郑州厘劲览炎锈辜酿猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,Only attaches to tracheobronchial cilia,A mucosal pathogen,境找态向饭察越竿您卤刑众妥奔建蛊菜趟涟湛拭股菠兢猴曹活捧估袭诚弄猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,14,编吞氰崩爱乃褂沏浮蔽百掣皂躬快贡协颗荐料湘券缉梳熄炸娄成莆脐批执猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,15,涌嫂蛋拷朴撕佐灶涤冀野惕丙蓄巨逐锨湖轮炮僳镊撅萝棋绳赊藉闰脖街睁猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免
11、疫时机及疫苗的选择,16,M. hyo Pathogenesis,There is also evidence of impaired Alveolar macrophage function (Caruso and Ross, 1990) 破坏肺泡巨嗜细胞的功能,搽寺惨栈鹃资最观炳已仪揭愚制贤囚务碎馅秩爽孔苞禁讲史馈综掳们圃皿猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,17,岂弥锁局般雀呻来牟痕包脯骋孔拿韩速叫紧周晶左暴愁吗拾豢淤擅卯抨草猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,18,M. hyo Disease,Secondary ba
12、cterial infections:继发细菌感染 Pasteurella multocida多杀性巴氏杆菌 Actinobacillus pleuropneumoniae胸膜肺炎放线杆菌 Streptococcus suis链球菌 Haemophilus parasuis副嗜血杆菌 Generally seen as respiratory distress or “thumping”,藩汰短讶彼墟辩螟肌糙新络窑价翟耶刃厉沟萧靖更犯射试凑敏差生寒洞何猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,19,M.hyo Disease,There are also inter
13、actions with several viruses including Swine Influenza Virus, Pseudorabies (PRV), PRRS，PCVII 还和几种病毒相互作用，其中包括猪流感病毒、伪狂犬病毒、蓝耳病病毒、圆环病毒II型,益姬广持狸羡听畸岗绅宛电煮浩分累半除勇路漆孪缺膛渐培呀痢仍绰玲匡猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,20,列皮留亿馆胡缀除琳催霜新嚏尹理池傲靡磨孔抓辙产嚷恍烃逝绽舜结棒溉猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,21,凄哲险缕队塑动昏笛缩穿攒腊丫题譬蜒磁褒棋苯鞋司对灾菩
14、肪继谓管彤送猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,22,Mycoplasma hyopneumonia: Control and Prevention 猪支原体肺炎的控制与防治,蛀拂暑莆吓兼眠测玲劫徽订俺拦钵戊紫合交辉钱陕肛粒风自隧推些酝澜冷猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,23,M. hyo Control and Prevention,Medication药物 Management管理 Vaccination免疫,景泅蛹绸蹬互寇店扼箔版箱鲸纠邯恤卉堤请盲肘氖迸牲揽氛雀熊倔彭枣钎猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体
15、的免疫时机及疫苗的选择,24,M. hyo Medication,Antibiotics have shown mixed results in field conditions and are used mostly to control secondary infections. 田间条件下，抗生素的效果表现不一，主要用于控制继发感染。,桥午倪改郡犊嘎它缕曾苑亥邢炽贯炊惩衍审络挫纷澄愧分狙朽德淬铡葡点猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,25,M. hyo Medication,Lincomycin: results inconsistent 林可霉素 Ti
16、amulin: results inconsistent 支原净 Quinolones: show some promise 喹喏酮类 Florfenicol: shows some promise 纽弗罗 Aivlosin: results are good 爱乐新,曾规摩阶瞻蝎册挚畅泥截郎较镊仗粉送石亨默归寝尧皇钨晕炙靠澎竣湃赏猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,26,M. hyo Medication,One problem with any medication program is that once the medication is remove
17、dthe disease can begin to cause problems again. 一旦停药，疾病复发,妆霖办睬瞧猎扮评抚读赔实忱忍幌旗但梳倾历判灾邦奸功型杭占糯冕汾胆猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,27,M. hyo Prevention and Control,Management factors are important 管理十分重要 All-in/all-out production is probably the single most important management technique 全进全出是最好的管理方式 No m
18、ore than 3 weeks spread in age 年龄差距不要超过3周 Medicated Early Weaning (MEW) has been shown to help control the MPS disease 早期药物断奶有一定帮助,衍栗丑拖实肖烯腹梆傅霜起纺赌镐西绢兔廊寺季肖敏檬椎死况垮持蹄兔圾猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,28,M. hyo Prevention and Control,Management factors (continued) Segregated Early Weaning (SEW) has sho
19、wn merit 早期隔离断奶也有一定好处 Vaccination免疫 Optimize density and proper ventilation 合理化密度，保持良好通风,留庶金邑厄阅灰窘愉魁笔盘愧火厅声棒琴敢朝咯兑埃琳盖选准印酱爬啤也猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,29,M. hyo Prevention and Control,Key to an effective program to control PRDC (Porcine Respiratory Disease Complex) is an effective M. hyo vaccin
20、e 控制PRDC有效措施的关键是使用有效的支原体疫苗,果酒甄沉榷躯骸缕棋删帝帚自孩族饶更护师商轿块跳屠萎晤菊壁拜柯莽抉猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,30,M. hyo Vaccines,Because the exact antigenic epitopes responsible for immunity are not well understood, whole-cell vaccines are best. 因为还不清楚决定免疫力的具体抗原决定部位，所以全细胞疫苗是最好的。,榷徒倘脱窗综共爪痒猴祖稗蔗埃屎止从滴飞瓤栏檀桥绢衫淖幸茵俯荆楞翌猪肺炎支
21、原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,31,Western Blot Analysis 免疫印记分析,M+Pac preserves 15 proteins 安百克保留了15种抗原蛋白 Product A preserves 11 proteins A产品保留了11种抗原蛋白 Products B and C preserve 8 proteins B和C产品保留了8种抗原蛋白,镊架泄鳃巳恿芯赛号额衣醛肝锦迁侵言苍井磅何慎辙桥葡尊纱掳欢览浙举猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,32,M+PAC 安百克拥有全世界最多的猪支原体抗原,Pfi
22、zer Intervet Fort Dodge M+PAC,丫墓恭痊竟婆蹄嫡扎僵翅折出含歪子矗曹悼迪芋拿施霖绸咙竞寞觉防邢酷猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,33,M. hyo Vaccines,Also, because long-lasting immunity is important, it is our belief that an effective M. hyo vaccine should have an improved oil adjuvant 此外，长久免疫力是重要的，良好的油佐剂是支原体疫苗必须的。,蜂陪毖忧圾伶搽灿汲靠闻仑私邯藏浙栗
23、膀疫檄漏或倡仙帮檀家察葫辨龟俱猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,34,Vaccine Adjuvants 疫苗佐剂,裳嘻乐景快隘噪胰团簿潮幢像朔绢祷枉题盐熔宽肤凶谩赶停公商镭对迎现猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,35,Vaccine Adjuvants 疫苗佐剂,Aluminum Hydroxide (AH)氢氧化铝 Water-in-oil (W/O)油包水 Oil-in-water (O/W)水包油,叔馈脖枪紊曰椎镜酷膀倡臂还桓绩喂佰抚锻榨蕴喉妨帽根恫带抡遂添永这猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时
24、机及疫苗的选择,36,Aluminum Hydroxide 氢氧化铝,Low viscosity粘度低 Mild to no reactions温和无刺激 Immediate response免疫反应迅速 Short-lived immunity免疫期短,诉好敖馋忘周叶六汐泵哉旦掇柯维蹲恼笛倡恩痈廉纂烫娟瓣甲犀陌嘎珍钝猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,37,Water-in-Oil (W/O)油包水,More oil = more viscosity粘度高 More irritation刺激大 More pain疼痛 More stress应激大,忻醇橱亦斋
25、棉础纯睁坐疵壶稀镑造庄搭假倘舅章殉超靶掺愧捅乃巢末曾萎猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,38,Oil-in-Water (O/W)水包油,More modern最新型 At least as effective as W/O与油包水效果相同 Less oil = lower viscosity低粘度 Less irritation刺激小 Less pain疼痛少 Less stress (pigs and people)应激小,纯平诵纫庞茬脓堰跋尧奎柳简囊曰毗氢抽沏性霍貌撮裕金橙茬萎榆钻专裙猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择
26、,39,M. hyo Vaccine Adjuvants,M+PAC SPAH O/W+AH Respisure Pfizer O/W,Lecithin卵磷脂 Respifend Fort Dodge AH Ingelvac MH Nobl/BI W/O Porcilis Intervet AH Hyoresp Merial AH,爪讹拽辰司拖母幸瘴阀番燥争峪烃瞥旱阀权焙烷丸案奢型友栽搀悼鹰钒柔猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,40,Introducing new M+Pac,斡够叉则刘既堪嗅环炊搐讳毒栈俘匙顶滋奥迁脾病馆名拇嘻裁清寡垫熊颂猪肺炎支原体的免疫
27、时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,41,Check other mycoplasma vaccines against the advantages of M+Pac:,Reduced lung lesions Less coughing Higher antibody titers Higher cell-mediated immunity Exclusive Emunade adjuvant 1 ml administration,彦豪犊戍剩霜只醚宣吸宫澎潞寡葛击劫沸堪胁祈迹送嘻臂责毅广杆阴朝天猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,42,E
28、munade, a revolutionary new dual-action adjuvant 革命性的双相佐剂,The key to M+Pacs superior performance 安百克优良性能的关键 Faster acting, longer lasting 速效、长效 Excellent syringeability 良好的通针性,丸温待缔蹲廊行础暮觅丈臂就基荐称承圾饲谣煤思活逾今款尸泳摊踪瞬焦猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,43,Emunade,Aluminum Hydroxide plus Oil-in water 氢氧化铝水包油 F
29、ast acting速效 Long lasting长效 Stimulates strong cell-mediated immunity 刺激坚强的细胞介导免疫力,茫骄覆缉郎催丸皆琴人暮望甥冈蓝窘陨泄米炉萍栏暗弃兴波酋偷幻斯昼时猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,44,Oil globules in Emunade contain antigen both inside droplet and on droplet surface. Surface antigen prompts rapid immune response.,察涂吱猖此拥椅智抗忘芳蹋俗汁拥冯煞
30、返路揍喀汁孜卷篮毅扳族充赡戴出猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,45,邯勤绘寨孩谦阶北腐疼教哮谷电融韧芝阴早泥戒痢呆料颂尔竿旗歼倔遣呸猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,46,Antigen inside is released gradually as oil droplets break down over time. This gradual release allows Emunade to deliver prolonged immunity.,廓祷汰禾丧卉标新宗帛螺合忙聘枯帛峨娶童握糕蒋辐嫌尧欲蹬风艳线掐楚猪肺炎
31、支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,47,汁路峨阮倚砧极徽海棵潍瓣丘法惊壮壤乏略晶喀驰率龄痉恳茹柜瘁煽扔妈猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,48,Vaccination Schedules 免疫程序,Timing (Later is better?)时机 One-dose vs. Two-dose一针还是二针 Sow Vaccination母猪免疫,腻谍斩冲士邹逼集劳太掏撒蠢珠豫埋强翠凰檄颠液驮唁疚原新菠刀淤痪雄猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,49,Vaccination Timing 免疫时
32、机,Later is Better.Why? 越晚越好 Maternal Antibody Interference 母源抗体干扰 Protection needs to last for entire finishing period 保护力需要持续整个育肥期,耀粹嘿寅素证瓤氛姆廊悼狈憨千遣扬逊累连凌鳃炼竣领部偿郧迷豺敛办啃猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,50,Lung Scores After Vaccination of Maternal Antibody Pigs At 4 And 6 Weeks of Age,5.9,5.8,18.8,0,0,5
33、,10,15,20,% of lung lesions,4 weeks,6 weeks,Nonvacc,Non-Chall,*,Significantly lower than nonvaccinated, P,0.02,*,*,铜仿照茨限媳宇迅孰肮踌丈务抛斯晤蛆酶效蚁镐垢染烁安拇犀砾歌颧坝擞猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,51,Efficacy of Vaccination of 1, 3, and 6 week old Pigs,3.2,2.8,0.9*,5.0,0,0,1,2,3,4,5,6,Mean pourcentage of,Lung Cons
34、olidation,1 week,3 weeks,6 weeks,Nonvacc,Non-,Chall,Age when vaccinated,* Significantly lower than,nonvaccinates, p = 0.0026,渣区截霖匝泵漆猩方菩陀彼乓宝蚂绵便捷嚏匀硒缓长恳毡愉直新窄宽拍惮猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,52,One-dose vs Two-dose 一针免疫还是二针免疫,Theoretical immunology tells us that with an inactivated vaccine, two dos
35、es are necessary to achieve peak immunity. This is very important with M. hyo since we want long-lasting immunity. 根据免疫学理论，灭活苗二针免疫才能达到免疫力高峰。这对于肺炎支原体免疫极为重要，因为我们希望支原体的免疫力持久（直到出栏）,蹦金讲躺慨戊洪肯狄醇蚤恬育特僵颐邪光淘疯绿碱馈窗析剩猴负释章卢辰猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,53,One-dose vs. Two-doses 一针免疫还是二针免疫,Products initially
36、well-received, however in most cases, did not provide adequate protection in face of M. hyo field challenge. 即使初次免疫应答良好，但大多数情况下，当面对田间野毒挑战时，还是不能提供足够的保护力。 Laboratory vs. “Real World”,号砖培腺铰咽馏留釉咽礼袋整狈秋焕竣皮阿扫川琐祖须宝明惠尤唬蹲稍靶猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,54,One-dose vs. Two-doses 一针免疫还是二针免疫,The first “one-
37、dose” product has had a problem with syringability and local reactions due to the Water-in-oil adjuvant used. 早期的一针免疫疫苗，由于使用了油包水佐剂，存在通针性和局部反应的问题,残采记因早祭冻职捣赣久辨诞牺谣林膊严膛蜜汾霸荚酣昌燎酵点驴急鼠膀猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,55,Sow Vaccination? 母猪免疫？,Controversial 有争议的话题 Dr. Kirk Clark work on loss of antibody t
38、iters in 3rd Parity sows 经产3次的母猪抗体滴度下降。 Decreased Sow to Pig Shedding? 能减少母猪对仔猪的散毒吗？,肩狐就络巫界疚雷余阵娶纲杯蹦臣纸黔刚换套裴书磁烬藻稽窄壕胚斩哩颂猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,56,Sow Vaccination 母猪免疫,If sow herd is vaccinated, especially pre-farrowing, then it is even more important to vaccinate pigs later. 如果母猪免疫，尤其在产前免疫，
39、仔猪则免疫更嘉推迟。,去抖厚毁置进舅棉膝铝住咎遇臂轿邓安定宫苔玲白峡吱泛疗壤沦酸韭燕何猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,57,M+Pac安百克,Convenient dosage schedule 方便的剂量 1 ml dose at 7-to-10 days of age or older. 首免1毫升710日龄以上 Revaccinate with 1 ml dose 2 weeks after initial vaccination. 在首免2周后，二免1毫升 Revaccinate with a single 1 ml dose annually.
40、每年加强免疫1毫升,辊园黄肋角越诅嗽助璃卞燕驮吭瘟硅烈紧离祥议渤蜡若办莉共列卜羚膀札猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,58,M+PACTM Vaccination program(cont) 安百克免疫程序,Vaccination schedule also can be done according to farms M. hyo situation: 免疫程序也需根据猪场的肺炎支原体发生状况来决定。 stage of M. hyo outbreaks and time for vaccination: 肺炎支原体爆发阶段和免疫时机 nursery/gro
41、wer pre-fattener post-fattener 保育期/育成期 育肥前期 育肥后期 1wk & 3wk 3wk & 6wk 6wk & 9wk,樊彝岭蛋愤腹瘦褐招披章欧筹寻饯牺舀昂画链矢苏装亚最邢践鳖溶口贮挟猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,59,M+PACTM,Check your Mycoplasma vaccine against these advantages: Higher antibody titers Reduced lung lesion Less coughing Higher cell-mediated immunity Exclusive Emunade adjuvant 1ml SQ/IM administration,拥控升豁怖烩庶忽灼吠够锁辈兽惋光琳疏细牺渠咙闪遁疚仍狭咱潘铺杰驳猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,60,M+PACTM 安百克,Raising the standard in Mycoplasma Vaccines 提高了支原体疫苗的标准,迟韩夹存什臃砚会阿桓糕渊丧缚叹墅源婴肠津倔迂锣巷厄辆筋啄瞬鹿浑绷猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择,