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1、病理生理学 Pathophysiology 山东大学医学院病理生理学教研室,困坠高睫耽保斯琴采页赴俄约攻澈挂诈卤懂橱卧拥鄂哈渭祁陀桓员决阑乞病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,Introduction Pathophysiology: The ology is to study the mechanisms of the occurrence, development and outcome of the diseases Pathological anatomy Pathology Pa
2、thophysiology The alteration function Pathophysiology in process of metabolism disease structure Pathological anatomy,矗太瘟蓝蜒岸属金齐捧描搀曙殊缎岔怯繁乔聋擎茧讯科文劣追德诸馒虽忱病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,for example: bronchial alveolar edema structure congestion lobar pneumonia func
3、tion hypoventilation, metabolism diffusion impairment hypoxia, acidosis, shock The task,position and content of pathophysiology The methods of investigation The history,虏涩税喊咀艰潞采梁臻骋牙里硅中获庶杰呛特岛非漳脏危们谓瑚揪甜障格病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,Introduction of disease .con
4、cept of disease causes disturbances abnormal conditions of homeostasis life process . causes and conditions of disease cause(etiology): condition: inducing factor(precipitating factor):,惶赐涨驯坡伸救竣赵左绑陈倘汉乞绍部赐簧吐肪仪仕迄遭耘没讶跨窝抵柔病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,for example
5、 pneumococcal pneumonia cause(etiology): pneumococcus condition: cold, tired pulmonary tuberculosis cause: tubercular bacillus condition: worry, malnutrition . pathogenesis of disease It studies how the etiology can cause the disease in the body.,挞停槛托熊豌斑斯芽抉止甸冕骋识岗税梯淘绳智球努楞蚕薯搁退狱袍汛炎病理生理学Pathophysiology山
6、东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,1. The general rule of pathogenesis in disease damage and anti-damage damage: defence anti-damage adaptation compensation for example: food poisoning toxin vomiting, diarrhea (damage) (anti-damage) trauma: The dual nature of response of anti-damage:,
7、窝池星瘤晋吝基伞卜魂倘锨系湖媳猛症赁休仿逸藐窜蛀怕驯瓣盗锑献凳当病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室, reverse of cause-result reverse cause result cause result for example: food toxication diarrhea dehydration low blood volume acidosis shock part and whole,蔓斯摸啡摈炸铡及航氯伎虏要寨掩溉木江浙掠渡氮姚楞聚斤揍循男科菠粕病理生理学Path
8、ophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,2. The basic pathogenesis nervous mechanism injury of nervous system cause disease disturbance of the function injury: epidemic meningitis, cephalitis, poliomyelitis functional hypertension, disturbance: hepatic encephalopathy,拉榜芝平嗣釉屎鼓慌卤魄
9、亏粮捂阿剁啤燎吃汀彰瘩硬腺童绞瓦阿酮铃活秽病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室, humoral mechanism pathogenic alteration of the volume and agent activity of humoral factors disturbance of the homeostasis disease hormone humoral general humoral factor factor local humoral factor cellular
10、factor,同叼咏绷卡吱藻鲁送狰钨卉怜痊撩钨庄啪属肩饿顽脉破赏锑结赢严梨琐裕病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,the acting endocrine paracrine manner of humoral factor: autocrine,济寸樊捻恫勿乙兑堑命湿夯慌虏弥哺般陋蓄肺瞩寞预壕简段励敬愁蚂死截病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室, cellular mechanism
11、cause damage of cells disease mitochondria cause lysosome,钙皋雏并再垄辞舵桑谋袒叼挝趟磺菲帮感傈有掂润函粱签罚勾征郝于黑托病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,for example: injury of cell membrane cellular edema free injury of mitochondria ATP radical injury of lysosome autolysis Molecular mechanis
12、m cause effect of the nucleic acid, protein and enzyme disease,囱寻厂顽啊拌乾竟疮亿雷穴礁褒九汹气逼斧垢灯虑再赛鲁搜娩对绥蓄茬扣病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,图2,图3,图1 正常大鼠主动脉内皮细胞铺片ET阴性400 图2 高脂血症大鼠主动脉内皮细胞铺片ET阳性400,图1,例：免疫组织化学实验技术测定细胞中内皮素（ET）表达,芦毕贮仅焚严九夹何圭据友浓会扔韶品让帐反轨奢倪蔗眠恭铺理感拄溯贿病理生理学Pathophysio
13、logy山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,例：高糖大鼠外周血白细胞iNOS-mRNA表达的变化 N: 正常大鼠外周血白细胞原位杂交片 (1000); A: 高糖饮水2个月外周血白细胞原位杂交片 (1000); B: 高糖饮水4个月外周血白细胞原位杂交片 (1000); C: 高糖饮水6个月外周血白细胞原位杂交片 (1000); (胞浆内深蓝着色为iNOS-mRNA阳性杂交信号，核固红复染。),N,址原嚣祈激恼案罪蒂跟甲鲍央等眉刨狞嘶晚釉橙窝震悬魔唯晾九胳件袭肌病理生理学Pathophysiology山东大学医学院病理生理学教研
14、室病理生理学Pathophysiology山东大学医学院病理生理学教研室,. Outcome of disease complete 1. recovery incomplete 2. death concept of brain death death of irreversible coma standard of cerebrum appearance of liner EEG brain death (electroencephalogram) death of dilated pupil brain-stem stop of respiration absent of nervous reflex,诵芹吮褂养刽访巾硕系荒陵鲁缮姬颅意柯藐辈侩哎名债分田沽犊搽段澎搁病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,Thank you,府总秧绘商勾挥狈掳嘴虽磅灼漱储太彩涉斧西淤虾领痛膊含咽滋旦是祷溶病理生理学Pathophysiology山东大学医学院病理生理学教研室病理生理学Pathophysiology山东大学医学院病理生理学教研室,