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1、食欲调控-外周、中枢与应激 Appetite Regulation-Peripheral, Central and the Role of Stress,宋志刚 山东农业大学动物科技学院,Richards MP, Proszkowiec-Weglarz M. 2007. Mechanisms regulating feed intake, energy expenditure, and body weight in poultry. Poult Sci. 86:1478-90.,Hormonal regulation of appetite,Orexin （食欲素） Leptin(瘦素) I
2、nsulin(胰岛素) Adiponectin (脂联素 ) Ghrelin（生长素） PYY PP(胰多肽) GLP-1 (胰高血糖素样肽1) OXM(胃泌酸调节素) CCK(胆囊收缩素),Stanley S, Wynne K, McGowan B, Bloom S. 2005. Hormonal regulation of food intake. Physiol Rev. 85: 1131-58.,Nutrient regulation of feed intake,Fatty acid (脂肪酸) Glucose (葡萄糖) Amino acid (氨基酸),Carol K.L. La
3、m, Madhu Chari and Tony K.T.Lam. 2009. CNS regulation of glucose homeostasis. Physiology. 24: 159-170.,Tony K.T. Lam, Gary J. Schwartz and Luciano Rossetti. 2005. Hypothalamic sensing of fatty acids. Nature Neuroscience. 8: 579-584.,Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ
4、. 2006. Hypothalamic mTOR signaling regulates food intake. Science. 312: 927-30.,Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferr P, Birnbaum MJ, Stuck BJ, Kahn BB. 2004. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalam
5、us. Nature. 428: 569-74.,Richards MP, Proszkowiec-Weglarz M. 2007. Mechanisms regulating feed intake, energy expenditure, and body weight in poultry. Poult Sci. 86:1478-90.,Effects of feeding ad lib (7d), fasting (8d) and refeeding (9d) on hypothalamic AMPK and (an)orexigenic peptide mRNA levels,Z.
6、Song, L. Liu, H. Lin, E. Decuypere and J. Buyse. 2010. Fasting induces an increase in AMPK2 gene expression in the hypothalamus of broiler chicks. Meeting abstract, Pama, Italy.,Shimizu H, Arima H, Ozawa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. 2010. Glucocorticoids increase
7、NPY gene expression in the arcuate nucleus by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Peptides. 31: 145-9.,Shimizu H, Arima H, Ozawa Y, Watanabe M, Banno R, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y. 2010. Glucocorticoids increase NPY gene expression in the arcuate nucleus
8、by inhibiting mTOR signaling in rat hypothalamic organotypic cultures. Peptides. 31: 145-9.,Lei Liu, Lixian Zhu, A. Sheikh Ahmadi, Zhigang Song, Hongchao Jiao, Hai Lin. 2010. Heat stress and corticosterone contribute differently to the expression of appetite-related genes in laying hens. Poult. Sci.
9、 (submitted),Lei Liu, Lixian Zhu, A. Sheikh Ahmadi, Zhigang Song, Hongchao Jiao, Hai Lin. 2010. Heat stress and corticosterone contribute differently to the expression of appetite-related genes in laying hens. Poult. Sci. (submitted),研究展望,禽类与哺乳动物相比较，生理代谢存在显著不同，同一种信号物质，在禽类和哺乳动物上的作用是否相同，尚需深入研究。 动物发生应激时，体内能量发生重新分配，蛋白质、糖类和脂肪代谢发生显著变化。应激引起的这些代谢变化对下丘脑中的食欲调控因子和调控通路的作用以及作用途径，有待进一步澄清。,