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1、Lab 6diseases of the cardiovascular system,gross specimens Acute rheumatic endocarditis Repeated rheumatic endocarditis Aortic stenosis Hypertensive heart disease Arteriolar nephrosclerosis Brain hemorrhage Atherosclerosis of the aorta/coronary,Normal structure of heart,Normal tricuspid valve,二尖瓣亚急性
2、细菌性心内膜炎,47. Acute rheumatic endocarditis 48. Rheumatic myocarditis 50. Primary arteriolar nephroslcerosis 51. Aortic atherosclerosis 52. Coronary atherosclerosis,Tissue sections,First to recognize the valve and the vegetations. There are mucoid degeneration, fibrinoid necrosis and inflammatory infil
3、tration. Vegetations mainly consist of pink trabecular platelets and red fibrin network with RBC in it.,47. Acute rheumatic endocarditis,48. Rheumatic myocarditis,Aschoff body consists of central fibrinoid necrosis with a perimeter of Aschoff cell, lymphocyte.,Aschoff cells have abundant basophilic
4、cytoplasm and single or multiple central round-to-ovoid nuclei in which the chromatin is disposed in the central zone. In cross section “owl eye” appearance, cut longitudinally resemble a “caterpillar”.,50.primary arteriolar nephrosclerosis,The afferent glomerular arteriole: hyaline degeneration Som
5、e of glomeruli suffered fibrosis, hyaline degeneration，atrophy, disappear Other glomeruli suffered compensatory hypertrophy; renal tubule dilate，and protein cast can be seen.,51. Aortic atherosclerosis 52. Coronary atherosclerosis,Local intima thicken apparently; surface of intima is fibrous cap with hyaline degeneration.,The light stained area is necrotic substance, cholesterol crytstal and calcification under the cap. Media is compressed and become thinner.,