《阿尔采默氏病用药指南.doc》由会员分享，可在线阅读，更多相关《阿尔采默氏病用药指南.doc（14页珍藏版）》请在三一文库上搜索。
1、 -GABAB1B6ADB1(PET)AD-GABAGABAnootropics-GABApiracetamoxiracetamaniracetamnefiracetam1 PiracetanAcetamide Pyrrolidone()ATPADP EB1B2B62 OxiracetamNeurometNeupan 1974201) 2)C(protein kinase C,PKC) 3) 4) 5) ATP/ADP3 Aniracetam 1988199322 67.647.5%71.7%56.2%123:0.26635min840.811CO2()4nefiracetamcAMPCa2+
2、5pramiracetamParke-remen,Neupramir1993DihydroergotoxineCo-dergocrine Mesylate5-HTTmax0.51.5h512% 1. 2. 1234 1 Almitrine -15 1 23/452 3Nicergoline - ChEI1 velnacrineTacrine FDAPTYLSTIGMINEPHENSERINE2 Galanthamin Hydrobrmide LycoremineLycoris radiate (L Her) Herb. 3 Huperzine A ADAchEAch4 Metrifonate ADADADADASAlzheimerDisease Assess-ment Scale5 donepezilAricept (ChE) (AchE)Ca2+AchE(BchE)1 250ChE()()() ,19961125FDA,1997,199910,50,6 rivastigmineExelonb-(APP) ENS163LY246078Dup996M1 NMDAN-D-(NMDA)FDA1(Alzheimers disease,AD),ADmemantine hydrochloride memantine hydrochlorideN-D-NMDANMDA