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1、The Wnt Signaling Pathway,Jennifer Slade B.Sc. (Hon) M.Sc. Candidate,Outline,Introduction Overview of Wnt signaling Components of Wnt signaling Wnt proteins Palmitoylation Transport Wnt receptors Interactions with extracellular proteins How they signal,Cytoplasmic Signaling cascade Nuclear Signaling
2、 Cascade Target genes Non-Wnt pathway genes Feedback loop Mutant Wnt Pathway Phenotypes Wnt Redundancy Wnt and Human Disease Summary,Introduction,Important in multiple developmental events Mutated: leads to disease Canonical pathway: Wnt signaling through Frizzled to -catenin Main intracellular proteins involved: Dishevelled (Dsh)- Glycogen synthase kinase 3 Axin(GSK-3) catenin- Adenomatous Polyposis Coli (APC) Wnt signaling inhibits degradation of -catenin -catenin interacts with Tf lymphoid enhancer-binding factor (TCF),Overview of Pathway,Dsh,Dsh,APC,GSK3,Axin,-c,