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1、【附表1】附表为常见的糖脂代谢通路主要蛋白，供参考。糖代谢通路主要蛋白检测序 号蛋白名缩写蛋白名全称生物过程1InsIn sulin胰岛素信 号通路2IRIn suli n receptor3p-IR(Tyr1150/1151)Phospho-insulin receptor (Tyr1150/1151)4p-IR (Tyr 1146)Phospho-i nsuli n receptor (Tyr 1146)5IGF1R( IR)In suli n-like growth factor 16CREBcAMP resp onse eleme nt-b inding7p-CREB(Ser 133)
2、Phospho-cAMP response element-binding (Ser133)8C/EBP a p42CCAAT-e nhan cer-b inding protei ns p429p-C/EBP a p42Phospho- CCAAT-e nhan cer-b inding prote ins p4210p-p38 MAPKPhospho-p38 mitoge n-activated prote in kin ase11p44/42 MAPKp44/42 mitoge n-activated prote in kin ase12p-p44/42 MAPK (Thr202/Tyr
3、204)Phospho-p44/42 mitogen-activated protein kinase (Thr202/Tyr204)13p70s6kp70S6 kin asep-p70s6k(Thr421/Ser424)Phospho-p70S6 kin ase14Aktseri ne/thre onine prote in kin ase15p- Akt (Ser473)Phospho-seri ne/thre onine protein kin ase (Ser473)16p- Akt (Ser308)Phospho-seri ne/thre onine protein kin ase
4、(Ser308)1718IRSIn suli n receptor substrate19p-IRSPhospho -in suli n receptor substrate20p-IRS (Ser 307)Phospho -in suli n receptor substrate (Ser 307)21Pte nphosphatase and tensin homolog22Socs1suppressor of cytok ine sig nali ng prote ins 123Socs3suppressor of cytok ine sig nali ng prote ins 324PG
5、C-1 aperoxisome proliferator-activatedreceptor- 丫coactivator-1 a25PPARyperoxisome proliferator activated receptor gamma26PTP-1BProte in tyros ine phosphatase-1B27UCP1un coupli ng prote in 128UCP2un coupli ng prote in 229AMPKAMP-activated prote in kin ase30p-AMPKPhospho- AMP-activated protein kin ase
6、31ACCAcetyl-coA carboxylase32p- ACCPhospho-Acetyl-coA carboxylase333435GSK3Bglycoge n syn thase kin ase 3 beta36P-GSK3B (Ser9)Phospho-glycoge n syn thase kin ase 3 beta (Ser9)37P-GSK3BPhospho-glycoge n syn thase kin ase 3 beta38Pdx-1Pan creatic and duode nal homeobox 139PI3KPhosphatidyli no sitol 3-
7、k in ases40Sir2silent information regulator 241SIRT1sile nt mati ng type in formatio nregulati on 2homolog 142p-p90rsk(ser380)Phospho-p90 ribosomal S6 kinase (ser380)43Pax-6Paired box gene 644Histo ne4(Ac16)Histo ne 4 (Ac16)45Glycoge nGlycoge n其它46TubulinTubuli n47Acti nActi n48Glut4Glucose tran spo
8、rter type 4脂代谢通路主要蛋白检测序 号蛋白名缩写蛋白名全称生物过程1Aacsacetoacetyl-CoA syn thetase2Aasdhamino adipate-semialdehyde dehydroge nase3Acaa1aacetyl-Coe nzyme A acyltra nsferase 1A4Acaa2acetyl-Coe nzymeAacyltra nsferase2(mitoch on drial 3-oxoacyl-Coe nzyme A thiolase)5Acox1acyl-Coe nzyme A oxidase 1, palmitoyl6Acoxl
9、acyl-Coe nzyme A oxidase-like7Adipor1adip onectin receptor 18Adipor2adip onectin receptor 29Apoa2apolipoprote in A-II10Cpt1aearn it ine palmitoyltra nsferase 1a, liver脂肪酸代11Cpt1bearn it ine palmitoyltra nsferase 1b, muscle谢过程12Cyb5cytochrome b-513Ehhadheno yl-Coe nzymeA, hydratase/3-hydroxyacylCoen
10、zyme A dehydroge nase14Faahfatty acid amide hydrolase15Fabp2fatty acid binding prote in 2, in testi nal16Hpgdhydroxyprostagla ndin dehydroge nase 15 (NAD)17Hsd17b4hydroxysteroid (17-beta) dehydroge nase 418Lipalysosomal acid lipase A19Lipclipase, hepatic20Pparaperoxisome proliferator activated recep
11、tor alpha21Ucp3un coupli ng prote in 3 (mitoch on drial,prot oncarrier)22Acaa2acetyl-Coe nzymeAacyltra nsferase2(mitoch on drial 3-oxoacyl-Coe nzyme A thiolase)脂肪酸B 氧化过程23Adipoqadip onectin, C1Q and collage n doma in containing24Ppardperoxisome proliferator activator receptor delta25Apoalapolipoprot
12、e in A-I胆固醇合成过程26Fdftlfarn esyl diphosphate farn esyl tran sferase 127Fdpsfarn esyl diphosphate syn thetase28Pmvkphosphomeval on ate kin ase29Acbd3acyl-Coe nzyme A bin di ng doma in containing 3类固醇合成30Cyp51cytochrome P450, family 5131Hi nt2histidine triad nucleotide binding protein 232Lsslano sterol syn thase33Pbx1pre B-cell leukemia transcription factor 1胆固醇代 谢过程34Pmvkphosphomeval on ate kin ase35Srd5a1steroid 5 alpha-reductase 136Srd5a2steroid 5 alpha-reductase 237Tspotran slocator prote in38Srebf2sterol regulatory element binding factor 2