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1、紫杉醇脂质体对小细胞肺癌（Paclitaxel liposome in small cell lung cancer）Paclitaxel liposomes do not play a role in small cell lung cancerShihua52five return.UID7891 post 820 elite 0 1404 points 244 hours online registration time 2008-7-23 last login 2010-6-7 personal space Short Message buddy offline 1# and publ
2、ished in the 2009-5-4 22:36 only see the authorPaclitaxel liposomes do not play a role in small cell lung cancer(Paclitaxel liposome for injcetion)2008-11-23 18:07:28 Author: anonymous source: Chinese cancer network views: 132 text size: great in smallAbstract: name drug trade name: Paclitaxel gener
3、ic name: Paclitaxel liposome for injcetion Pinyin: Zhusheyong zishanchun zhizhiti paclitaxel Liposome for Injection English: Chemical Name: the main ingredients of this product for Taxol, taxol chemistry.Keyword: Paclitaxel liposome for injcetionname of drugPeptide namePaclitaxel liposome for injcet
4、ionChinese Pinyin: Zhusheyong, zishanchun, zhizhitiEnglish Name: Paclitaxel, Liposome, for, InjectionChemical name: the main ingredients of this product for paclitaxel, taxol chemical called 5 beta, 20- epoxy -1, 2 alpha, beta 7, beta 4, 10, 13 and six alpha hydroxy taxanes -11- ene -9- ketone -4, 1
5、0- two -2- acetate benzoate -13(2 R, 3 S) -N- benzoyl -3- phenyl isoserine esterThe chemical structure of taxol:Molecular formula of paclitaxel: C47H51NO14We will study the use of non small cell lung cancerFirst, let me know what I know first1, Iressa, Tarceva2, chemotherapy (carboplatin or cisplati
6、n): Gemcitabine and vinorelbine (Changchun n-desmethyl Changchun methylcytisine, Gainor, Norway, the paclitaxel), West (Zibin alcohol docetaxel and docetaxel, Tesoti),3, Endostar4, Pemety Jose (A Lingda, Dorjimmy, Alimta)5 bevacizumab (Avastin)6, DCA7, MAP (mitomycin C Changchun VDS DDP)CAP regimen
7、(cyclophosphamide, doxorubicin or epirubicin, cisplatin)Etoposide / carboplatinCyclophosphamide doxorubicin etoposide in never heard of anyone using any of these.I have used the drug for bone metastasis: Bonin, Ai LangTraditional Chinese medicine: Qingfei Sanjie capsule, ginseng capsule, Xiao Aiping
8、Lets have a look and add a lot of medicine. I heard it for the first timeThe West Zibin alcohol (docetaxel, Ai Su and sauty) is a kind of medicine, one thing.We used etoposide. It is generally believed that for small cells.We have used three kinds of Chinese medicine, and also used cantharidin capsu
9、le, denied the Zijin dragon tabletsChangchun Rui bin, go to a Changchun flower alkali (Gainor) is a kind of, are Nuo WeibenMolecular weight of paclitaxel: 853.92character this product is a kind of white or pale yellow lump.pharmacology and toxicologypharmacological actionThis product is cytotoxic an
10、ticancer drugs, can promote microtubule dimer assembly and prevent its depolymerization, can also lead to the abnormal arrangement of microtubules throughout the cell cycle and cell division during astral microtubules, thus preventing cell division, inhibit tumor growth.Toxicological studiesGenetic
11、toxicity in vitro (human lymphocyte chromosome aberration test) and in vivo (micronucleus test) test showed that paclitaxel is a clastogenic agent, but in the Ames test and CHO/HGPRT gene mutation test no mutagenicity.The reproductive toxicity of rats: during mating and before mating with paclitaxel
12、, dose of 1mg/kg/ day (according to body surface area reduced, about 0.04 times the recommended clinical maximum dose) or more, can lead to injury fertility of female and male rats, at this dose, the increase fertility and reproductive index decreased and embryo toxicity.Rabbits were given paclitaxe
13、l for 3mg/kg/ days during organ formation, which was converted by body surface area,About 0.2 times the maximum recommended dose on the clinical day can cause intrauterine death, fetal absorption, fetal death, fetal and fetal toxicity, and maternal toxicity. The dose of 1mg/kg/ days (according to bo
14、dy surface area conversion, about the clinical date, recommended the maximum dose of 1/15), there is no teratogenic effect. At higher doses, the teratogenicity of this product could not be evaluated because of a large number of fetal deaths. There is no sufficient and strictly controlled clinical da
15、ta for pregnant women. If the patient uses the product during pregnancy or is pregnant during the use of the product, the childs potential risk to the fetus should be told. Women of childbearing age who receive this treatment should avoid pregnancy.It was not known whether the product was excreted f
16、rom human milk, and the rats were given intravenous carbon -14 labeled paclitaxel at 9-10 days after delivery. The concentration of radioactivity in the milk was higher than that in the plasma and attenuated in parallel with the plasma concentration. In view of the fact that many drugs can be excret
17、ed from human milk and that this product may cause severe adverse effects on the breast fed infants, it is recommended that breastfeeding be stopped at the time of receiving this treatment.pharmacokinetics it is reported that cancer patients after infusion of paclitaxel, the drug in plasma was bipha
18、sic elimination, the average elimination half-life for 5.3-17.4 hours, 89%-98% drugs and plasma protein binding, plasma Cmax is related to the dosage and the infusion time, only a small amount of drug excreted in urine.indicationsThis product can be used in the first-line chemotherapy of ovarian can
19、cer and the treatment of metastatic ovarian cancer, as first-line chemotherapy, this product can also be combined with cisplatin.This product can also be used for subsequent treatment or recurrence of breast cancer patients who have been treated with standard chemotherapy with doxorubicin.This produ
20、ct can be used in combination with cisplatin for first-line chemotherapy in non - small cell lung cancer patients who cannot undergo surgery or radiotherapy.usage and dosageThe usual dose is 135 175mg/m2, before using 10ml was added to 5% glucose solution in the bottle, the oscillator shake for 5 mi
21、nutes, until completely dissolved after injection 250-500ml 5% glucose solution, the use of disposable infusion intravenous drip in line with national standards for 3 hours.For the prevention of allergic reactions of paclitaxel may occur, in 30 minutes before using this product, please carry out the
22、 following pretreatment: intravenous injection of dexamethasone intramuscular injection of diphenhydramine 5-10mg; 50mg; intravenous cimetidine 300mg.adverse effects1, allergic reactions: manifested as flushing, rash, breathing difficulties, hypotension and tachycardia, such as severe allergic react
23、ions, should be discontinued and treated, patients who have allergies should not use this product again.2. Myelosuppression: as the main dose limiting toxicity, manifested as neutrophil decrease, thrombocytopenia is rare, usually occurs 8-10 days after medication. The incidence of severe neutrophil
24、depletion was 47%, the incidence of severe thrombocytopenia was 5%, and anemia was more common.3 、 neurotoxicity: the incidence of peripheral neuropathy was 62%, the most common manifestations were mild numbness and paresthesia, and the incidence of severe neurotoxicity was 6%.4, cardiovascular toxi
25、city: low blood pressure and asymptomatic short duration of bradycardia, muscle and joint pain, the incidence of 55%, occurred in the limbs joints, the incidence and severity of dose dependent.5, gastrointestinal reactions: nausea, vomiting, diarrhea and mucositis incidence were 59%, 43% and 39%, ge
26、nerally mild and moderate.6, liver toxicity: ALT, AST and AKP elevated.7, hair loss: the incidence was 80%.8, local response: infusion of drugs intravenously and extravasation of drugs, local inflammation.taboo1, paclitaxel allergy is prohibited.2. Neutrophils less than 1500 /mm3 are forbidden.matte
27、rs needing attention1. The peripheral blood picture and liver function should be checked regularly during the period of medication.2. This product can only be dissolved and diluted with 5% Glucose Injection. It can not be dissolved or diluted by physiological saline or other solution, so as to avoid
28、 accumulation of liposome. This product is soluble in 5% Glucose Injection,Stable at room temperature (25 DEG C) and indoor light for 24 hours.3, liver dysfunction is used with caution.pregnant women and lactating women have not been systematically studied for pregnant women. If it is used in pregna
29、nt women or during the use of this product, the patient should immediately inform the patient of the potential danger. Lactating women must discontinue breastfeeding if they use this product.drug interactionPharmacokinetic data showed that the clearance rate of this product was about 30% lower after
30、 cisplatin was given to this product. The toxicity of bone marrow is serious. At the same time, ketoconazole was used to influence the metabolism of this product.drug overdose there is no corresponding antidote. The most predictable complications associated with overdose include myelosuppression, pe
31、ripheral nerve toxicity, and mucositis.specifications 30mg/ bottles, 8 bottles / boxes, a bottle of 1300 yuanstorage shading, airtight, stored at 2 - 8 degreespacking in packaging by white white ground card carton packaging, each small box of 1 bottles per box in box 8.validity tentative one and a h
32、alf years (see packing box for validity)approval number H20030357manufacturer Enterprise Name: Nanjing CISCO Pharmaceutical Co., Ltd.Hello, uncle shihua! In February, I went to Beijing, when my mother was in good condition. Most of the doctors in Beijing suggested keeping well. Do not catch cold, bu
33、t take some Chinese medicine right at the most. Also went to Tiantan Park, but the road with seven to around eight around quite late to catch up with the Lingong Guo station counseling time, but also very love music and the atmosphere in the park.But in March, when the mother checked, the disease de
34、veloped again, a new lung tumor, the brain metastasis. The doctors plan was weekly chemotherapy (paclitaxel), followed by three weeks rest, followed by 20 weeks of brain radiotherapy. But after 2 weeks of chemo, my mothers white blood cells were so low that she couldnt keep up, and I felt that her c
35、ondition was not improving, coughing, vomiting and loss of appetite were worse. Now rested for 2 weeks, and as planned, the taxol will be on again this week.I doubt the efficacy of paclitaxel. My father talked to the doctor yesterday, but the doctor thought the plan was more appropriate. After takin
36、g the CT, how about this afternoon?.Looking at mom so uncomfortable, and we are helpless. I wonder if there are any other plans for the present situation?CT came out, it was really invalid. 2 times the bitter taste of taxol.exceedUIWe also used paclitaxel for chemotherapy, but we didnt do it. Non-sm
37、all cell lung adenocarcinoma. Adenocarcinoma of lung, http:/ (Taxol Taxol) it is also useful to the treatment of small cell lung cancer. The effective rate of non small cell lung cancer is 23%Steele (paclitaxel Taxotere Tax-otere), the efficiency of 2354% in non-small cell lung cancerPaclitaxel lipo
38、somes also act on non small cell lung cancerBecause we are not clear about the composition of these drugs, and the rate of effectiveness is low, doctors are feeling the stones across the river.Doctors are saying that they are resistant to drugs, and what drugs they also have a headache. Because of t
39、he rapid development of the disease, now the left lung is oppressed, atrophic, atelectasis, breathing extremely difficult, electrolyte disorders, pleural effusion a lot (four days before and after 2300 or so have been pumped), the quality of life is very low. Chest water after smoking will feel bett
40、er, and can lie down on the rest, but this malignant water, the longer the longer pumping, people are more weak. I dont know what to do. Is there anyone who has experience?My father used chemotherapy with paclitaxel and cisplatin for the first three times. The effect was good. The sputum was relieve
41、d and the tumor was narrowed.Question: what are the drugs used for the treatment of adenocarcinoma?Does anyone know? All kinds of medication, domestic, imported, including the cost, say, thank youUID12260 post 21, essence 0 points 11, read permissions 20, online time 18 hours, registration time 2009
42、-3-16, finally login 2010-1-1, view detailsTOPWalkerseven * miracleUID12676 post 4107 elite 0 2054 points 804 hours online registration time 2009-4-3 last login 2010-6-7 personal space Short Message buddy offline 2# and published in the 2009-5-4 22:40 only see the authorThe range is too widePrices v
43、ary from place to placeUID12676 post 4107, essence 0 points 2054, read permissions 90, online time 804 hours, registration time 2009-4-3, finally login 2010-6-7, view detailsTOPAnpingIntroduction of new patientsUID13189 post 4 Elite 0 2 points 6 hours online registration time 2009-4-25 last login 20
44、10-1-3 personal space Short Message buddy offline 3# and published in the 2009-5-5 00:43 only see the authorCommonly used chemotherapy protocols and drug introductions for lung cancer (2008-08-29, 16:40:19)At present, domestic lung cancer chemotherapy often adopts the scheme:I. non-small cell lung c
45、ancerThe MAP program - repeated every 28 daysMitomycin 8MG/M2, IV, 1,5,10 days3MG/M2 IV Changchun two days 1,9Cisplatin, 120MG/M2, IVD, 1,5 daysRepeat CAP scheme - twenty-eighth daysCyclophosphamide, 400MG/M2, IV, first daysAdriamycin, 40MG/M2, IV first days60-80MG/M2 IV or epirubicin for first days
46、Cisplatin, 100MG/M2, IVD, first daysCE program - repeat for twenty-first daysCarboplatin, 325MG/M2, IV, first days100MG IV day 1-5 of etoposideNP every 4 weeks for 1 cycles.Changchun vinorelbine (Nuo Weiben) 25-30MG/M2 IV day 1,8,15,22,29Cisplatin, 120MG/M2, IVD, 1,29 daysPEV, repeated every 21 days
47、.Cisplatin, 70MG/M2, IVD, first daysEpirubicin 70MG/M2 IV for first days100MG/M2 IV day 1-3 of etoposideThe ICE program - repeats every 28 daysIfosfamide 1G/M2 IV for first days (3 hours)MESNA, 500MG/M2, IV, 0,4,8,12 hours (after IFO treatment)100MG/M2 IV day 1-3 of etoposideCarboplatin, 120MG/M2, IV, 1-3 daysThe PC program - repeats every 21 daysPaclitaxel, 135-175MG/M2, IV, first daysCarboplatin, AUG6.0-7, IV, second daysThe MIP program - repeats every 21 daysMitomycin 6MG/M2 IV for first